Size | Price | Stock |
---|---|---|
5mg | $300 | In-stock |
10mg | $450 | In-stock |
50mg | $1200 | In-stock |
100mg | $1700 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100431A |
M.Wt: | 325.36 |
Formula: | C13H11NO5S2 |
Purity: | >98 % |
Solubility: | DMSO : 2 mg/mL (6.15 mM; Need ultrasonic); H2O : 1 mg/mL (3.07 mM; ultrasonic and warming and heat to 80°C) |
IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1]. IC50 & Target: IC50: 0.5 μM (Notch)[1] In Vivo: IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration[1].
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