IMR-1A
CAS No. : 331862-41-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $450 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1700 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-100431A |
| M.Wt: | 325.36 |
| Formula: | C13H11NO5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (6.15 mM; Need ultrasonic); H2O : 1 mg/mL (3.07 mM; ultrasonic and warming and heat to 80°C) |
IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1]. IC50 & Target: IC50: 0.5 μM (Notch)[1] In Vivo: IMR-1A (2 mg/kg (i.v.) and 100 mg/kg (i.p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i.v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- IMR-1A
- Cat. No.:
- HY-100431A
- Quantity:
Your information is safe with us.