Size | Price | Stock |
---|---|---|
1mg | $70 | In-stock |
5mg | $120 | In-stock |
10mg | $180 | In-stock |
25mg | $390 | In-stock |
50mg | $700 | In-stock |
100mg | $1250 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-103482 |
M.Wt: | 360.45 |
Formula: | C16H16N4O2S2 |
Purity: | >98 % |
Solubility: | DMSO : 100 mg/mL (277.43 mM; Need ultrasonic) |
JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. IC50 & Target: IC50: 440 nM (MMP-9 zymogen)[1] In Vitro: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species[1]. In Vivo: The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose[1].
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