Trimethoprim 3-oxide


CAS No. : 27653-67-4

(Synonyms: Trimethoprim 3-N-oxide)

27653-67-4
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Cat. No. : HY-100645
M.Wt: 306.32
Formula: C14H18N4O4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 27653-67-4 :

Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim[1]. In Vitro: Trimethoprim 3-oxide is the primary metabolite of trimethoprim[1].
Trimethoprim 3-oxide (3-NO-TMP) is converted from trimethoprim by CYP1A1 and CYP1B1 with highest rates in human liver microsomes (HLMs). The CYP1A inhibitor α-Naphthoflavone inhibits Trimethoprim 3-oxide formation, however, other competitive P450 inhibitors has no obvious inhibition on the formation[1].

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