JPM-OEt
CAS No. : 262381-84-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $480 | In-stock |
| 10mg | $760 | In-stock |
| 50mg | $2650 | In-stock |
| 100mg | $4200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-102087 |
| M.Wt: | 392.45 |
| Formula: | C20H28N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (318.51 mM; Need ultrasonic) |
JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2].
In Vivo: JPM-OEt (50 mg/kg; i.p.; daily for 30 days) reduces tumor cathepsin B activity significantly[1].
JPM-OEt (50 mg/kg; i.p.; twice daily for 4 weeks) leads to tumor regression in the RIP1-Tag2 (RT2) mouse model of pancreatic islet cell tumorigenesis[2].
JPM-OEt (50 mg/kg; i.p.; daily from 63 to 98 days) causes a significant delay in the increase of tumour burden during the first 2 weeks of treatment[3].
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