QX-314 (bromide)
CAS No. : 24003-58-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $650 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-101350 |
| M.Wt: | 343.30 |
| Formula: | C16H27BrN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (145.65 mM; ultrasonic and warming and heat to 60°C); H2O : 100 mg/mL (291.29 mM; Need ultrasonic) |
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].
IC50 & Target: sodium channel[1]
In Vitro: QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro [1].
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[1].
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death [1].
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude [3].
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- [3].
In Vivo: QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin[2].
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