Clozic


CAS No. : 22494-47-9

(Synonyms: ICI 55897; Clobuzarit)

22494-47-9
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Cat. No. : HY-100142
M.Wt: 304.77
Formula: C17H17ClO3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 22494-47-9 :

Clozic is a potential anti-arthritic agent. In Vitro: Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media[1].

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