KW-8232


CAS No. : 217813-15-5

217813-15-5
Price and Availability of CAS No. : 217813-15-5
Size Price Stock
5mg $500 In-stock
10mg $850 In-stock
25mg $1800 In-stock
50mg $3000 In-stock
100mg $4600 In-stock
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500 mg Get quote
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Cat. No. : HY-100304A
M.Wt: 705.26
Formula: C37H41ClN4O6S
Purity: >98 %
Solubility: DMSO : 125 mg/mL (177.24 mM; Need ultrasonic)
Introduction of 217813-15-5 :

KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1]. IC50 & Target: Prostaglandin Receptor[1] In Vitro: KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].
In Vivo: KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].

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