JAK2 JH2 Tracer


CAS No. : 2101955-00-2

2101955-00-2
Price and Availability of CAS No. : 2101955-00-2
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1mg $150 In-stock
5mg $450 In-stock
10mg $750 In-stock
50mg $2500 In-stock
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Cat. No. : HY-102055
M.Wt: 747.73
Formula: C38H27F2N7O6S
Purity: >98 %
Solubility: DMSO : ≥ 83.3 mg/mL (111.40 mM)
Introduction of 2101955-00-2 :

JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2]. In Vitro:JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM[1].
JAK2 JH2 Tracer shows a dissociation constants near 0.2 µM[1].
JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments[1]. In Vivo:The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2].
Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2].

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