Size | Price | Stock |
---|---|---|
1mg | $150 | In-stock |
5mg | $450 | In-stock |
10mg | $750 | In-stock |
50mg | $2500 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-102055 |
M.Wt: | 747.73 |
Formula: | C38H27F2N7O6S |
Purity: | >98 % |
Solubility: | DMSO : ≥ 83.3 mg/mL (111.40 mM) |
JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2]. In Vitro:JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM[1]. JAK2 JH2 Tracer shows a dissociation constants near 0.2 µM[1]. JAK2 JH2 Tracer shows a high binding affinity with a Kd value of 0.2 μM for JAK2 JH2 domain by saturation experiments[1]. In Vivo:The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2]. Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2].
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