Size | Price | Stock |
---|---|---|
1mg | $100 | In-stock |
5mg | $220 | In-stock |
10mg | $350 | In-stock |
50mg | $1200 | In-stock |
100mg | $2100 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-101564 |
M.Wt: | 483.36 |
Formula: | C22H23BrN6O2 |
Purity: | >98 % |
Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer[1][2]. IC50 & Target:IC50: 0.14 nM (PRMT5)[2] In Vitro:Onametostat binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. Onametostat shows potent and broad inhibition of cellular growth[1]. In Vivo:Oral administration of Onametostat results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome, in several non-small cell lung cancer and small cell lung cancer cancer mouse xenograft models[1].
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