WNK463
CAS No. : 2012607-27-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $760 | In-stock |
| 100mg | $1200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100626 |
| M.Wt: | 463.46 |
| Formula: | C21H24F3N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 30 mg/mL (64.73 mM) |
WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK)-kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively[1].
IC50 & Target: IC50: 5 nM (WNK1), 1 nM (WNK2), 6 nM (WNK3), and 9 nM (WNK4)[1]
In Vitro: WNK463 (50 nM, 1 μΜ, 10 μΜ; 6 days; Human tissue-engineered corneas (hTECs)) treatment reduces phosphorylation of the WNK1 downstream targets SPAK/OSR1 in wounded hTECs.
In Vivo: WNK463 (1-10 mg/kg; oral administration; 4 hours; Spontaneously hypertensive Sprague Dawley rats) treatment produces dose-dependent decreases in blood pressure and simultaneous increases in heart rate in conscious SHRs. WNK463 produces significant and dose-dependent increases in urine output as well as urinary sodium and potassium excretion rates.
WNK463 is orally bioavailable in Sprague Dawley rats with a half-life of 2.1 hours[1].
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