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Cat. No. : | HY-10383 |
M.Wt: | 531.60 |
Formula: | C31H33NO7 |
Purity: | >98 % |
Solubility: | DMSO |
J-104132 is a potent, orally active ETA/ETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells. IC50 & Target: Ki: 0.034 nM (human ETA receptor, CHO cell), 0.104 nM (human ETB receptor, CHO cell)[1] In Vitro: J-104132 is a potent, orally active mixed ETA/ETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells. J-104132 also shows Ki of 0.350 ± 0.158 nM for ETA receptor in human uterus and 0.343 ± 0.146 nM for ETB receptor in human hippocampus[1].
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