TRAM-39


CAS No. : 197525-99-8

197525-99-8
Price and Availability of CAS No. : 197525-99-8
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10mg $135 In-stock
25mg $270 In-stock
50mg $430 In-stock
100mg $680 In-stock
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Cat. No. : HY-103308
M.Wt: 303.78
Formula: C20H14ClN
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 197525-99-8 :

TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4]. IC50 & Target:IC50: 60 nM (KCa3.1 channel)[4] In Vitro:TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells[2].
TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells[3]. In Vivo:TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations[1].

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