TAPI-2


CAS No. : 187034-31-7

(Synonyms: TNF Protease Inhibitor 2)

187034-31-7
Price and Availability of CAS No. : 187034-31-7
Size Price Stock
1mg $198 In-stock
5mg $792 In-stock
10mg $1254 In-stock
50 mg Get quote
100 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-100211
M.Wt: 415.53
Formula: C19H37N5O5
Purity: >98 %
Solubility: DMSO : ≥ 22 mg/mL (52.94 mM); H2O : 100 mg/mL (240.66 mM; Need ultrasonic)
Introduction of 187034-31-7 :

TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP[1]. TAPI-2 blocks the entry of infectious SARS-CoV[2]. IC50 & Target:IC50: 20±10 μM (MMP)[1] Ki: 1.5±0.27 nM (MMPs)[1] In Vitro: The hydroxamate-based metalloprotease inhibitor TAPI-2 bounds to hmeprin with inhibition constants IC50 20±10 μM for hmeprin β subunit and 1.5±0.27 nM for hmeprin α subunit. Generally, hmeprin α is inhibited more strongly than the β subunit[1]. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5-40 μM)[3].

Your information is safe with us.