TPMPA


CAS No. : 182485-36-5

182485-36-5
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Cat. No. : HY-101359
M.Wt: 161.14
Formula: C6H12NO2P
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 182485-36-5 :

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3]. IC50 & Target: KB: 2.1 μM (GABAC) In Vitro: TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1].
TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2]

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