Size | Price | Stock |
---|---|---|
10mg | $117 | In-stock |
50mg | $488 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-15762 |
M.Wt: | 314.36 |
Formula: | C16H14N2O3S |
Purity: | >98 % |
Solubility: | DMSO : ≥ 34 mg/mL (108.16 mM) |
Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain. IC50 & Target:IC50: 5 nM (COX-2), 140 μM (COX-1)[1] In Vitro: Valdecoxib (Compound 2) is a highly potent, selective and orally active inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively[1]. Valdecoxib (10, 100 µM) inhibits LPS-induced proliferation of endothelial cells and bFGF secretion in a dose-dependent manner. Valdecoxib stimulates VEGF formation via HMEC-1 under inflammatory conditions[2]. In Vivo: Valdecoxib (Compound 2) shows potent oral activity in an acute antiinflammatory assay (rat carrageenan foot pad edema; ED50 = 10.2 ± 1.4 mg/kg). Valdecoxib also has chronic antiinflammatory activity in the rat adjuvant arthritis model, with an ED50 of 0.032 ± 0.002 mg/kg/day[1]. Valdecoxib (10 mg/kg, i.p.) significantly attenuates the behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice[3].
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