LY2365109 (hydrochloride)
CAS No. : 1779796-27-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100416A |
| M.Wt: | 421.91 |
| Formula: | C22H28ClNO5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL (73.48 mM); H2O : < 0.1 mg/mL (insoluble) |
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].
In Vivo: LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine[1].
LY2365109 hydrochloride increases seizure thresholds in mice[2].
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