Size | Price | Stock |
---|---|---|
1mg | $41 | In-stock |
5mg | $88 | In-stock |
10mg | $143 | In-stock |
25mg | $320 | In-stock |
50mg | $520 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-10167A |
M.Wt: | 340.29 |
Formula: | C18H23Cl2NO |
Purity: | >98 % |
Solubility: | DMSO : 50 mg/mL (146.93 mM; Need ultrasonic) |
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].
In Vitro: Tecalcet (NPS 568, 0.1-100 μM) increase [Ca2+]i in a concentrationdependent and stereoselective manner[3].
Tecalcet (NPS 568, 0.1-100 nM) shiftes the concentration-response curve for extracellular Ca2+ to the left without affecting the maximal response and, thereby, decreases
the EC50 value for extracellular Ca21 to 0.61±0.04 mM[3].
In Vivo: Tecalcet (1.5 and 15 mg/kg, orally, twice daily for 4 days) inhibits PT cell proliferation in rats with renal insufficiency[1].
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