Tecalcet (Hydrochloride)


CAS No. : 177172-49-5

(Synonyms: R-568 (hydrochloride))

177172-49-5
Price and Availability of CAS No. : 177172-49-5
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Cat. No. : HY-10167A
M.Wt: 340.29
Formula: C18H23Cl2NO
Purity: >98 %
Solubility: DMSO : 50 mg/mL (146.93 mM; Need ultrasonic)
Introduction of 177172-49-5 :

Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3]. In Vitro: Tecalcet (NPS 568, 0.1-100 μM) increase [Ca2+]i in a concentrationdependent and stereoselective manner[3].
Tecalcet (NPS 568, 0.1-100 nM) shiftes the concentration-response curve for extracellular Ca2+ to the left without affecting the maximal response and, thereby, decreases the EC50 value for extracellular Ca21 to 0.61±0.04 mM[3].
In Vivo: Tecalcet (1.5 and 15 mg/kg, orally, twice daily for 4 days) inhibits PT cell proliferation in rats with renal insufficiency[1].

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