Tetrindole (mesylate)
CAS No. : 170964-68-8
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| Cat. No. : | HY-101169 |
| M.Wt: | 390.54 |
| Formula: | C21H30N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity[1][2]. In Vitro:Tetrindole mesylate has IC50s of 0.51-1.37 μM for 6 human breast tumor cell lines (MCF-7, HCC1954, T47D, MDA-MB-157, ZR75-1, BT474)[2]. In Vivo:Tetrindole mesylate (25 mg/kg; po; single dose) inhibits rat brain and liver mitochondrial MAO A by 80% within 0.5-1 hr and the onset of recovery of enzyme activity became evident after 24 hr in male albino rats weighing 180-200 g[1].
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