E4CPG
CAS No. : 170846-89-6
(Synonyms: (RS)-ECPG)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $480 | In-stock |
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| Cat. No. : | HY-100372 |
| M.Wt: | 223.23 |
| Formula: | C11H13NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (44.80 mM; ultrasonic and adjust pH to 12 with NaOH); H2O : 1 mg/mL (4.48 mM; ultrasonic and warming and heat to 80°C) |
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation[1][2].
In Vitro: E4CPG acts at rat cortical mGluR with the KB value of 0.367 mM[3].
In Vivo: E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) [4].
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats[5].
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