KW-8232 free base
CAS No. : 170365-25-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $850 | In-stock |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
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| Cat. No. : | HY-100304 |
| M.Wt: | 609.16 |
| Formula: | C36H37ClN4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].
IC50 & Target: Prostaglandin Receptor[1]
In Vitro: KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].
In Vivo: KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].
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