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HY-100202

CAS:16858-02-9

 (Synonyms  TPEDA)
16858-02-9  Technical Data: Price and Availability of  Cas No:16858-02-9

Cas : 16858-02-9 M.Wt: 424.5407
Cas : 16858-02-9 Formula: C26H28N6
Cas : 16858-02-9 Purity: >98 %
Cas : 16858-02-9 Storage: at 20℃ 2 years
Cas : 16858-02-9 Solubility: 10 mM in DMSO
Cas : 16858-02-9 Name: TPEN
USD
50mg/$50 In-stock
100mg/$80 In-stock
200mg/$120 In-stock
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16858-02-9  Data Sheet:
 
Introduction of 16858-02-9 :
TPEN is a specific cell-permeable heavy metal chelator. Target: InVitro: Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca2+. In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca2+[1]. TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage[2].
 
References on 16858-02-9 :
 

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