Size | Price | Stock |
---|---|---|
25mg | $50 | In-stock |
100mg | $130 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-B1920 |
M.Wt: | 827.99 |
Formula: | C42H69NO15 |
Purity: | >98 % |
Solubility: | H2O : 8.33 mg/mL (10.06 mM; ultrasonic and adjust pH to 6 with HCl); DMSO : ≥ 41.67 mg/mL (50.33 mM) |
Josamycin (EN-141) is a macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM. IC50 & Target: Kd: 5.5 nM (ribosome)[1] In Vitro: Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin[1]. In Vivo: Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels[2].
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