CGP60474
CAS No. : 164658-13-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $130 | In-stock |
| 50mg | $425 | In-stock |
| 100mg | $695 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-11009 |
| M.Wt: | 355.82 |
| Formula: | C18H18ClN5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL (140.52 mM) |
CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor[1][2][3].
IC50 & Target: IC50: 84 nM (VEGFR-2)[1]
PKC[2]
In Vitro: CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM[1]. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP[2].
In Vivo: CGP-60474 (10 mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model[2].
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