CAS:1644060-37-6

1644060-37-6 Technical Data:

Price and Availability of Cas No:1644060-37-6

Cas : 1644060-37-6 M.Wt: 446.5381
Cas : 1644060-37-6 Formula: C27H30N2O4
Cas : 1644060-37-6 Purity: >98 %
Cas : 1644060-37-6 Storage: at 20℃ 2 years
Cas : 1644060-37-6 Solubility: 10 mM in DMSO
Cas : 1644060-37-6 Name: Fumarate hydratase-IN-1

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1644060-37-6 Data Sheet:

Introduction of 1644060-37-6 :
Fumarate hydratase-IN-1, an enzyme of the TCA cycle. Inhibition of fumarate hydratase-IN-1 can contribute to tumorigenicity in some cells. The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target.[1] In vitro: The activity of this enzyme was measured using a well-established assay that monitored the conversion of fumarate into L-malate and subsequent oxidation of L-malate to oxaloacetate by malate dehydrogenase. Initial controls established that neither the carboxylic acid 3 nor ester 2 inhibited malate dehydrogenase Using this two-enzyme protocol we found that carboxylic acid 3 inhibited fumarate hydratase in a dose-dependent fashion in vitro. Besides, inhibition of fumarate hydratase can contribute to tumorigenicity in some cells.[1]

References on 1644060-37-6 :

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