WIN 64338 (hydrochloride)


CAS No. : 163727-74-0

163727-74-0
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Cat. No. : HY-101368A
M.Wt: 783.94
Formula: C45H69Cl2N4OP
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 163727-74-0 :

WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM)[1][2]. IC50 & Target: Ki: 64 nM (bradykinin B2 receptor)[1], 350 nM (muscarinic receptor)[2] In Vitro: WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated 45Ca2+ efflux from IMR-90 cells (pA2=7.1)[1].
WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA2=8.2)[1].
WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a KB of 64.3 nM[2]. In Vivo: WIN 64338 (5 mg/kg; i.p.) hydrochloride decreases the physiological anxiety measure, stress-induced hyperthermia (SIH) of mice[3].

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