Esaxerenone


CAS No. : 1632006-28-0

(Synonyms: CS-3150; XL-550)

1632006-28-0
Price and Availability of CAS No. : 1632006-28-0
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1mg $80 In-stock
5mg $180 In-stock
10mg $290 In-stock
25mg $560 In-stock
50mg $890 In-stock
100mg $1400 In-stock
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Cat. No. : HY-100471
M.Wt: 466.47
Formula: C22H21F3N2O4S
Purity: >98 %
Solubility: DMSO : 100 mg/mL (214.38 mM; Need ultrasonic)
Introduction of 1632006-28-0 :

Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist[1]. IC50 & Target: Mineralocorticoid receptor[1] In Vivo: After single oral administration of Esaxerenone at 0.1, 0.3, 1, and 3 mg/kg, maximum plasma concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration (Tmax) of Esaxerenone ranges from 2.0 to 4.5 h. After intravenous administration of Esaxerenone at 0.1, 0.3, 1, and 3 mg/kg, the total body clearance (CL) and distribution volume at steady state (Vss) are 3.53 to 6.69 mL/min/kg and 1.47 to 2.49 L/kg, respectively, in rats, and 2.79 to 3.69 mL/min/kg and 1.34 to 1.54 L/kg, respectively, in cynomolgus monkeys. Up to 168 h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168 h is 11.5% in urine, 82.3% in feces, and 93.9% in total[1].

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