LY3177833
CAS No. : 1627696-51-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $62 | In-stock |
| 5mg | $132 | In-stock |
| 10mg | $185 | In-stock |
| 50mg | $528 | In-stock |
| 100mg | $845 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100023 |
| M.Wt: | 309.30 |
| Formula: | C16H12FN5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 30 mg/mL (96.99 mM) |
LY3177833 (Example 4) is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 is a senescence inducer[1][2]. IC50 & Target:IC50: 3.3 nM (CDC7), 290 nM (pMCM2)[1] In Vitro:LY3177833 (10 μM; 4 days) increases SA-β-gal content in Hep3B cells[2]. In Vivo:LY3177833 (Example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dose-dependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].
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