Synaptamide
CAS No. : 162758-94-3
(Synonyms: N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide)
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| Cat. No. : | HY-100197 |
| M.Wt: | 371.56 |
| Formula: | C24H37NO2 |
| Purity: | >98 % |
| Solubility: | Ethanol : 25 mg/mL (67.28 mM; Need ultrasonic) |
Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR)[1] [2][3].
In Vitro: Synaptamide (Dehydroepiandrosteron; DHEA) is a weak agonist at both CB1 and CB2 receptors[2].
In Vivo: Synaptamide (10 mg/kg; subcutaneously; daily for 7 days) promotes cognitive recovery in rats subjected to mild traumatic brain injury (mTBI)[1].
Synaptamide (2-10 mg/kg; adult male C57BL/6J mice) reduced the levels of nociceptive and inflammatory pain-related behaviour over 60 min in the intraplantar formaldehyde assay via both intraperitoneal and local intraplantar administration[2].
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