GSK481
CAS No. : 1622849-58-4
| Size | Price | Stock |
|---|---|---|
| 2mg | $60 | In-stock |
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 50mg | $435 | In-stock |
| 100mg | $700 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100131 |
| M.Wt: | 377.39 |
| Formula: | C21H19N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 35 mg/mL (92.74 mM) |
GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM[1]. IC50 & Target: IC50: 1.3 nM (RIP1), 2.8 nM (Ser166 phosphorylation in wild-type human RIP1)[1] In Vitro: GSK481 (300 nM; 2 hours; Jurkat cells) abrogates the RIP3 up-regulation induces by both TNFa and shikonin in live and dead cells, indicating that necroptosis is in fact induced by both agents[2]. In Vivo: GSK481 inhibits Ser166 phosphorylation in three mouse RIP1 mutants (IC50=18~110 nM) more potently than in wild-type mouse[1].
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