Z-Ile-Leu-aldehyde
CAS No. : 161710-10-7
(Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
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| Cat. No. : | HY-12465 |
| M.Wt: | 362.46 |
| Formula: | C20H30N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 41 mg/mL (113.12 mM) |
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].
In Vitro: Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2].
In Vivo: Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].
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