HA15


CAS No. : 1609402-14-3

1609402-14-3
Price and Availability of CAS No. : 1609402-14-3
Size Price Stock
5mg $96 In-stock
10mg $132 In-stock
50mg $420 In-stock
100mg $720 In-stock
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Cat. No. : HY-100437
M.Wt: 466.58
Formula: C23H22N4O3S2
Purity: >98 %
Solubility: DMSO : ≥ 50 mg/mL (107.16 mM)
Introduction of 1609402-14-3 :

HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity[1]. IC50 & Target: BiP/GRP78/HSPA5[1] In Vitro: HA15 (10 μM; 1-24 hours) induces an early endoplasmic reticulum stress (ER Stress)[1].
HA15 (0-10μM; 24 hours) decreases melanoma cell viability in a dose-dependent manner compared with control conditions (DMSO), with an IC50 of 1-2.5 μM in A375 cells[1].
HA15 (1-10 μM; 24 hours) induces apoptosis in A375 cells[1].
HA15 (1-24 μM; 24 hours) induces autophagy[1].
HA15 (10 μM; 48 hours) has high efficiency in inducing cell death and ER stress in BRAF-inhibitor-resistant melanoma cells. And HA15 inhibits tumor growth through autophagic and apoptotic mechanisms initiated by ER stress[1].
No deleterious effects on the viability of normal human melanocytes or human fibroblasts were observed with low or high doses of HA15[1].
In Vivo: HA15 (0.7 mg/mouse/day; i.h.; over 2 weeks) inhibits melanoma tumor development in mice, induces no apparent toxicity and no change in their behavior, body mass, or liver mass, suggesting an absence of hepatomegaly[1].
HA15 (0.7 mg/mouse; i.p.; 5 days/week) suppresses MPM tumor growth in vivo[3].

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