TX1-85-1


CAS No. : 1603845-32-4

1603845-32-4
Price and Availability of CAS No. : 1603845-32-4
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1mg $80 In-stock
5mg $160 In-stock
10mg $280 In-stock
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Cat. No. : HY-100848
M.Wt: 580.68
Formula: C32H36N8O3
Purity: >98 %
Solubility: DMSO : 3.85 mg/mL (6.63 mM; Need ultrasonic)
Introduction of 1603845-32-4 :

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1]. IC50 & Target: IC50:23 nM (ErbB3)[1] In Vitro: TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively[1].

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