Size | Price | Stock |
---|---|---|
1mg | $80 | In-stock |
5mg | $160 | In-stock |
10mg | $280 | In-stock |
50 mg | Get quote | |
100 mg | Get quote | |
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Cat. No. : | HY-100848 |
M.Wt: | 580.68 |
Formula: | C32H36N8O3 |
Purity: | >98 % |
Solubility: | DMSO : 3.85 mg/mL (6.63 mM; Need ultrasonic) |
TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1]. IC50 & Target: IC50:23 nM (ErbB3)[1] In Vitro: TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively[1].
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