VUF10166


CAS No. : 155584-74-0

155584-74-0
Price and Availability of CAS No. : 155584-74-0
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5mg $50 In-stock
10mg $80 In-stock
25mg $150 In-stock
50mg $250 In-stock
100mg $400 In-stock
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Cat. No. : HY-100552
M.Wt: 262.74
Formula: C13H15ClN4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 155584-74-0 :

VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1]. IC50 & Target: IC50: 40 nM (5-HT3AB); Ki: 0.04 nM (5-HT3A), 22 nM (5-HT3AB)[1]

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