Size | Price | Stock |
---|---|---|
5mg | $80 | In-stock |
10mg | $130 | In-stock |
25mg | $260 | In-stock |
50mg | $420 | In-stock |
100mg | $700 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100186 |
M.Wt: | 330.33 |
Formula: | C14H13F3N2O2S |
Purity: | >98 % |
Solubility: | DMSO : ≥ 33 mg/mL |
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness[1][2][3][4].
In Vitro:GSK-2881078 has EC50s of 4.44 μM and 3.99 × 10−3 μM for reporter gene of androgen inducible yeast and PC3(AR)2 cells (human prostate carcinoma cell), respectively[4].
GSK-2881078 (10−5-10 μM, 24 h) stimulates reporter gene expression dose-dependently in the PC3(AR)2, increasing the relative luminescence units from 140% to 17340%[4].
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