TAK-915


CAS No. : 1476727-50-0

1476727-50-0
Price and Availability of CAS No. : 1476727-50-0
Size Price Stock
5mg $820 In-stock
10mg $1300 In-stock
25mg $2600 In-stock
50mg $4160 In-stock
100mg $6650 In-stock
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Cat. No. : HY-103493
M.Wt: 458.36
Formula: C19H18F4N4O5
Purity: >98 %
Solubility: DMSO : 7.5 mg/mL (16.36 mM; ultrasonic and warming and heat to 60°C)
Introduction of 1476727-50-0 :

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment[1][2]. In Vivo: TAK-915 (3 mg/kg; oral administration; daily; for 4 days; male F344 rats) treatment significantly reduces escape latency in aged rats in the Morris water maze task[2].
TAK-915 (1, 3, and 10 mg/kg, p.o.) dose-dependently attenuates the non-selective muscarinic antagonist scopolamine-induced memory deficits in rats[2].
Oral dosing of TAK-915 (compound 36) (3 or 10 mg/kg) in mice produces a dose-dependent increase in 3',5'-cyclic guanosine monophosphate (cGMP) levels, with significant cGMP increases observed at a dose of 10 mg/kg[1].

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