ZYZ-488
CAS No. : 1470302-79-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 50mg | $1650 | In-stock |
| 100mg | $2250 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100472 |
| M.Wt: | 487.46 |
| Formula: | C20H29N3O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (410.29 mM; Need ultrasonic); H2O : ≥ 100 mg/mL (205.15 mM) |
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3[1].
IC50 & Target: Apoptotic protease activating factor-1[1]
In Vitro: ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3[1].
ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases[2].
In Vivo: ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis[2].
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