Flavopiridol


CAS No. : 146426-40-6

(Synonyms: L868275; HMR-1275; Alvocidib)

146426-40-6
Price and Availability of CAS No. : 146426-40-6
Size Price Stock
5mg $50 In-stock
10mg $70 In-stock
50mg $195 In-stock
100mg $360 In-stock
200mg $640 In-stock
500mg $990 In-stock
1g $1850 In-stock
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Cat. No. : HY-10005
M.Wt: 401.84
Formula: C21H20ClNO5
Purity: >98 %
Storage: at -20°C 3 years
Solubility: 10 mM in DMSO
Introduction of 146426-40-6 :

Flavopiridol is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively. IC50 & Target: IC50: 30 nM (CDK1), 170 nM (CDK2), 100 nM (CDK4)[3] In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].

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