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HY-10005

CAS:146426-40-6

 (Synonyms  L868275; HMR-1275; Alvocidib)
146426-40-6  Technical Data: Price and Availability of  Cas No:146426-40-6

Cas : 146426-40-6 M.Wt: 401.84
Cas : 146426-40-6 Formula: C21H20ClNO5
Cas : 146426-40-6 Purity: >98 %
Cas : 146426-40-6 Storage: at 20℃ 2 years
Cas : 146426-40-6 Solubility: 10 mM in DMSO
Cas : 146426-40-6 Name: Flavopiridol
USD
5mg/$50 In-stock
10mg/$70 In-stock
50mg/$310 In-stock
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146426-40-6  Data Sheet:
 
Introduction of 146426-40-6 :
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. IC50 Value: ~ 40 nM Target: CDK in vitro: Flavopiridol induces G1 arrest with inhibition of CDK2 and CDK4 in human breast carcinoma cells in a time and concentration dependent manner. Short time treatment of Flavopiridol (~12 hours) induce apoptosis in hematopoietic cell lines including SUDHL4, SUDHL6 (B-cell lines), Jurkat and MOLT4 (T-cell lines ), and HL60 (myeloid). In the clonogenic assay, Flavopiridol functions as a highly potent cytotoxic compound with a mean IC70 with 8 ng/mL in 23 human tumor models. A recent study shows Flavopiridol treatment induces a substantial AKT-Ser473 phosphorylation in human glioblastoma T98G cell line. in vivo: After treatment with 7.5 mg/kg Flavopiridol bolus intravenous (IV) or intraperitoneal on each of 5 consecutive days, 11 out of 12 advanced stage subcutaneous (s.c.) human HL-60 xenografts undergo complete regressions, and animals remain disease-free several months after one course of Flavopiridol treatment. SUDHL-4 s.c. lymphomas treated with flavopiridol at 7.5 mg/kg bolus IV for 5 days undergo either major (two out of eight mice) or complete (four out of eight mice) regression, with two animals remaining disease-free for more than 60 days. The overall growth delay is 73.2%.
 
References on 146426-40-6 :
 

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