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HY-10005

CAS:146426-40-6

 (Synonyms  L868275; HMR-1275; Alvocidib)
146426-40-6  Technical Data: Price and Availability of  Cas No:146426-40-6

Cas : 146426-40-6 M.Wt: 401.84
Cas : 146426-40-6 Formula: C21H20ClNO5
Cas : 146426-40-6 Purity: >98 %
Cas : 146426-40-6 Storage: at 20℃ 2 years
Cas : 146426-40-6 Solubility: 10 mM in DMSO
Cas : 146426-40-6 Name: Flavopiridol
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5mg/$50 In-stock
10mg/$70 In-stock
50mg/$310 In-stock
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146426-40-6  Data Sheet:
 
Introduction of 146426-40-6 :
Flavopiridol is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of around 40 nM. IC50 & Target: IC50: 40 nM (CDK) In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].
 
References on 146426-40-6 :
 

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