Flavopiridol
CAS No. : 146426-40-6
(Synonyms: HMR-1275; Alvocidib; L86-8275)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $92 | In-stock |
| 50mg | $257 | In-stock |
| 100mg | $475 | In-stock |
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| Cat. No. : | HY-10005 |
| M.Wt: | 401.84 |
| Formula: | C21H20ClNO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (82.94 mM; Need ultrasonic) |
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
IC50 & Target: IC50: 30 nM (CDK1), 170 nM (CDK2), 100 nM (CDK4)[3]
In Vitro: Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].
Flavopiridol (Alvocidib) also inhibits cyclin E1 and induces apoptosis[4].
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