GNE-495


CAS No. : 1449277-10-4

1449277-10-4
Price and Availability of CAS No. : 1449277-10-4
Size Price Stock
1mg $80 In-stock
5mg $120 In-stock
10mg $180 In-stock
50mg $450 In-stock
100mg $750 In-stock
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500 mg Get quote
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Cat. No. : HY-100343
M.Wt: 405.42
Formula: C22H20FN5O2
Purity: >98 %
Solubility: DMSO : 2.17 mg/mL (5.35 mM; Need ultrasonic)
Introduction of 1449277-10-4 :

GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM. IC50 & Target: IC50: 3.7 nM (MAP4K4)[1] In Vitro: GNE-495 is a potent and selective MAP4K4 inhibitor with efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency[1]. In Vivo: GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows good in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%)[1].

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