Size | Price | Stock |
---|---|---|
5mg | $100 | In-stock |
10mg | $195 | In-stock |
25mg | $320 | In-stock |
50mg | $512 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-101418 |
M.Wt: | 488.64 |
Formula: | C28H32N4O2S |
Purity: | >98 % |
Solubility: | DMSO : 100 mg/mL (204.65 mM; Need ultrasonic) |
JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology[1].
IC50 & Target: pKi: 7.9 (huaman P2X7), 8.7 (rat P2X7)[1]
In Vitro: JNJ-47965567 exhibits high affinity for human and rat P2X7 in membrane preparations of 1321N1 cells[1].
JNJ-47965567 does not block IL-6 and TNF-α release, under identical conditions (LPS and BZ-ATP) used for IL-1β and IL-18 release[1].
JNJ-47965567 attenuates IL-1β release with pIC50s of 6.7 ± 0.07 (human blood), 7.5 ± 0.07 (human monocytes) and 7.1 ± 0.1 (rat microglia), respectively, in native systems[1].
In Vivo: JNJ-47965567 (30-100 mg/kg; s.c.) attenuates IL-1β release induced by Bz-ATP[1].
JNJ-47965567 (30 mg/kg) attenuates amphetamine-induced hyperactivity and exhibits modest, yet significant efficacy in the rat model of neuropathic pain[1].
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