QS-21


CAS No. : 141256-04-4

(Synonyms: Stimulon)

141256-04-4
Price and Availability of CAS No. : 141256-04-4
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5mg $2300 In-stock
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Cat. No. : HY-101092
M.Wt: 1990.13
Formula: C92H148O46
Purity: >98 %
Solubility: DMSO : 100 mg/mL (50.25 mM; Need ultrasonic); H2O : 50 mg/mL (25.12 mM; Need ultrasonic)
Introduction of 141256-04-4 :

QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. IC50 & Target:NLRP3 inflammasome In Vivo: Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].

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