JNK-IN-7
CAS No. : 1408064-71-0
(Synonyms: JNK inhibitor)
| Size | Price | Stock |
|---|---|---|
| 1mg | $179 | In-stock |
| 5mg | $377 | In-stock |
| 10mg | $487 | In-stock |
| 50mg | $1315 | In-stock |
| 100mg | $2097 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15617 |
| M.Wt: | 493.56 |
| Formula: | C28H27N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (67.53 mM; Need ultrasonic) |
JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. IC50 & Target: IC50: 1.5 nM (JNK1), 2 nM (JNK2), 0.7 nM (JNK3)[1] In Vitro: JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C[1]. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function[2].
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