TP-3654
CAS No. : 1361951-15-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $288 | In-stock |
| 100mg | $460 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101126 |
| M.Wt: | 418.46 |
| Formula: | C22H25F3N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (119.49 mM; Need ultrasonic) |
TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. IC50 & Target: Ki: 5 nm(Pim-1), 239 nM (Pim-2), 42 nM (Pim-3)[1] In Vitro: TP-3654 demonstrates potent PIM-1 specific cellular activity in the PIM-1/BAD overexpression system with an average EC50 of 67 nM. TP-3654 treatment reduces levels of phospho-BAD in vitro using the bladder cancer cell line UM-UC-3. TP-3654 reduces colony growth of T24 and UM-UC3 cells, confirming the PIM-1–dependent growth for both cell lines[1]. In Vivo: Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity[1].
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