Xanomeline


CAS No. : 131986-45-3

(Synonyms: LY-246708)

131986-45-3
Price and Availability of CAS No. : 131986-45-3
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10mg $100 In-stock
25mg $200 In-stock
50mg $320 In-stock
100mg $510 In-stock
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Cat. No. : HY-105182
M.Wt: 281.42
Formula: C14H23N3OS
Purity: >98 %
Solubility: DMSO : 50 mg/mL (177.67 mM; Need ultrasonic)
Introduction of 131986-45-3 :

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2]. IC50 & Target: M1/M4[1][2] In Vitro: Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (>1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1]. In Vivo: Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3].
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3].

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