Size | Price | Stock |
---|---|---|
5mg | $60 | In-stock |
10mg | $100 | In-stock |
25mg | $200 | In-stock |
50mg | $320 | In-stock |
100mg | $510 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-105182 |
M.Wt: | 281.42 |
Formula: | C14H23N3OS |
Purity: | >98 % |
Solubility: | DMSO : 50 mg/mL (177.67 mM; Need ultrasonic) |
Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia[1][2].
IC50 & Target: M1/M4[1][2]
In Vitro: Xanomeline (0.1~10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (>1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current[1].
In Vivo: Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3].
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile.
Xanomeline inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects[3].
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