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130495-35-1  Technical Data: Price and Availability of  Cas No:130495-35-1

Cas : 130495-35-1 M.Wt: 402.9144
Cas : 130495-35-1 Formula: C22H27ClN2O3
Cas : 130495-35-1 Purity: >98 %
Cas : 130495-35-1 Storage: at 20℃ 2 years
Cas : 130495-35-1 Solubility: DMSO: ≥ 30 mg/mL
Cas : 130495-35-1 Name: SKF-96365 (hydrochloride)
5mg/$60 In-stock
10mg/$100 In-stock
50mg/$390 In-stock
100mg/$650 In-stock
200mg/$850 In-stock
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130495-35-1  Data Sheet:
Introduction of 130495-35-1 :
SKF-96365 hydrochloride, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2].
References on 130495-35-1 :

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