Size | Price | Stock |
---|---|---|
5mg | $66 | In-stock |
10mg | $110 | In-stock |
50mg | $429 | In-stock |
100mg | $715 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
We match the lowest price on market. |
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Cat. No. : | HY-100001 |
M.Wt: | 402.91 |
Formula: | C22H27ClN2O3 |
Purity: | >98 % |
Solubility: | H2O : 100 mg/mL (248.19 mM; Need ultrasonic); DMSO : 100 mg/mL (248.19 mM; Need ultrasonic) |
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells[1][2]. In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2].
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