Size | Price | Stock |
---|---|---|
5mg | $80 | In-stock |
10mg | $110 | In-stock |
25mg | $150 | In-stock |
50mg | $250 | In-stock |
100mg | $450 | In-stock |
250mg | $1000 | In-stock |
500mg | $1850 | In-stock |
1 g | Get quote | |
5 g | Get quote | |
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Cat. No. : | HY-100184 |
M.Wt: | 415.33 |
Formula: | C14H12F7N5S |
Purity: | >98 % |
Solubility: | DMSO : 50 mg/mL (120.39 mM; Need ultrasonic); Ethanol : 11.11 mg/mL (26.75 mM; Need ultrasonic) |
DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2].
IC50 & Target: IC50: 8.9 nM (PfDHODH)[1]
EC50: 4.3 nM (P. falciparum 3D7 parasites)[1]
In Vivo: DSM265 (0.5 to 75 mg/kg; Oral administration; twice daily; for 4 days; NOD-scid IL-2Rγnull (NSG) mice) has potent in vivo antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily). The maximum rate of parasite killing occurred at and above a dose of 13 mg/kg per day (6.4 mg/kg twice daily).
DSM265 has moderate terminal elimination half-life (t1/2) of 2-4 hours for mice (0.5 to 75 mg/kg, oral) [2].
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