DSM265


CAS No. : 1282041-94-4

1282041-94-4
Price and Availability of CAS No. : 1282041-94-4
Size Price Stock
5mg $80 In-stock
10mg $110 In-stock
25mg $150 In-stock
50mg $250 In-stock
100mg $450 In-stock
250mg $1000 In-stock
500mg $1850 In-stock
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Cat. No. : HY-100184
M.Wt: 415.33
Formula: C14H12F7N5S
Purity: >98 %
Solubility: DMSO : 50 mg/mL (120.39 mM; Need ultrasonic); Ethanol : 11.11 mg/mL (26.75 mM; Need ultrasonic)
Introduction of 1282041-94-4 :

DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2]. IC50 & Target: IC50: 8.9 nM (PfDHODH)[1]
EC50: 4.3 nM (P. falciparum 3D7 parasites)[1] In Vivo: DSM265 (0.5 to 75 mg/kg; Oral administration; twice daily; for 4 days; NOD-scid IL-2Rγnull (NSG) mice) has potent in vivo antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily). The maximum rate of parasite killing occurred at and above a dose of 13 mg/kg per day (6.4 mg/kg twice daily).
DSM265 has moderate terminal elimination half-life (t1/2) of 2-4 hours for mice (0.5 to 75 mg/kg, oral) [2].

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