JP1302 dihydrochloride
CAS No. : 1259314-65-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $165 | In-stock |
| 50mg | $528 | In-stock |
| 100mg | $825 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-103213 |
| M.Wt: | 441.40 |
| Formula: | C24H26Cl2N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (11.33 mM; ultrasonic and adjust pH to 5 with NaOH); H2O : 12.5 mg/mL (28.32 mM; Need ultrasonic) |
JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research[1][2][3].
IC50 & Target:Ki: 28 nM (α2C- adrenoceptor)[2].
Kb: 16 nM (α2C- adrenoceptor)[2].
In Vitro:JP1302 shows about 100-fold higher affinity than for α2A or α2B[1].
In Vivo:JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine (HY-B1272A)[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction[3].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- JP1302 dihydrochloride
- Cat. No.:
- HY-103213
- Quantity:
Your information is safe with us.