TC-A 2317 (hydrochloride)
CAS No. : 1245907-03-2
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| Cat. No. : | HY-103266 |
| M.Wt: | 392.93 |
| Formula: | C19H29ClN6O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1].
In Vitro: TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM[1].
In Vivo: TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight[1].
TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats[1].
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- TC-A 2317 (hydrochloride)
- Cat. No.:
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