Size | Price | Stock |
---|---|---|
2mg | $60 | In-stock |
5mg | $90 | In-stock |
10mg | $160 | In-stock |
25mg | $330 | In-stock |
50mg | $560 | In-stock |
100mg | $990 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100218A |
M.Wt: | 440.88 |
Formula: | C23H21ClN2O5 |
Purity: | >98 % |
Solubility: | DMSO : 100 mg/mL (226.82 mM; Need ultrasonic) |
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].
IC50 & Target: Glutathione peroxidase 4[1]
In Vitro: RSL3 (0-8 μM, 72 hours) potently reduces the viability of HN3 cells, with IC50s of 0.48 µM in HN3 and 5.8 µM in HN3-rslR cells, respectively[1].
RSL3 (0-8 μM, 24 hours) reduces the expression of GPX4 protein, increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].
In Vivo: RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with trigonelline in mice bearing HN3R cells.
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