JZL195
CAS No. : 1210004-12-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $82 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $490 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15250 |
| M.Wt: | 433.46 |
| Formula: | C24H23N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (115.35 mM; Need ultrasonic) |
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively[1].
IC50 & Target: IC50: 2 nM (FAAH), 4 nM (MAGL)[1]
In Vitro: JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively)[1].
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays[1].
In Vivo: JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay[1].
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