Tazarotenic acid
CAS No. : 118292-41-4
(Synonyms: AGN 190299)
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $820 | In-stock |
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| Cat. No. : | HY-101108 |
| M.Wt: | 323.41 |
| Formula: | C19H17NO2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].
In Vivo:Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1]
.
| Male | Female | Male | |
| Dose (mg kg-1) | 4.4 | 4.4 | 0.49 |
| AUC (μg h mL-1) | 9.31 (2.14) | 9.78 (1.36) | 0.594 (0.95) |
| CL (mL min-1 kg-1) | 7.96 (1.59) | 7.62 (0.85) | 14.0 (2.2) |
| k (h-1) | 0.562 (0.339) | 0.820 (0.146) | 0.741 (0.115) |
| T1/2 (h) | 1.64 (0.92) | 0.86 (0.14) | 0.95 (0.16) |
| V0 (L kg-1) | 0.43 (0.05) | 0.49 (0.06) | 1.31 (1.15) |
| Vβ (L kg-1) | - | - | 1.14 (0.09) |
| Vmax (μg min-1) | 9.08 (2.89) | 6.09 (1.22) | - |
| Km (μg mL-1) | 7.09 (1.35) | 5.12 (1.19) | - |
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